Month: April 2018

Genetic testing in childhood cancer: a Pediatric Cancer Genome Project update

Eight years ago, as then-scientific director of St. Jude, I proposed an idea to the leaders of St. Jude Children’s Research Hospital: to map the genomes of some of the world’s most aggressive and least-understood childhood cancers. We would compare the complete genomes from both cancerous and normal cells to pinpoint the genetic factors underlying these diseases. Looking back, it was an audacious proposal. At that time, not even one pediatric cancer genome had been sequenced. The public and private large-scale sequencing projects then underway largely ignored pediatric cancer because, compared to adults, relatively few children and teens develop...

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