Category: Research

Latin American hospitals implement tool to identify kids whose condition is deteriorating

Posted by Mary Powers | Nov 1, 2022

Flexible and tailored implementation strategies helped pediatric cancer centers across Latin America scale up a proven quality improvement strategy.

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New model mimics progression of pediatric bone marrow failure

Posted by Alex Generous, PhD | Oct 4, 2022

St. Jude scientists have created the first model that faithfully recapitulates details of pediatric bone marrow failure.

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CDK6: A well-known kinase commits a new ‘crime’ connecting outer radial glia to microcephaly

Posted by Erin Podolak | Sep 27, 2022

Microcephaly is a rare neurodevelopmental condition in which a baby’s head is much smaller than expected because the brain did not develop properly or stopped developing during pregnancy. St. Jude researchers identified cells in the outer radial glia in the developing brain that play an important role in microcephaly.

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Environment helps fuel hepatoblastoma in premature infants

Posted by Erin Podolak | Sep 13, 2022

The incidence of pediatric and adult liver cancer is increasing worldwide. Research suggests how premature birth may influence the risk for children.

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Two Years of the Pediatric Translational Neuroscience Initiative

Posted by Alex Generous, PhD | Sep 1, 2022

St. Jude initiative aims to change the outlook for children with catastrophic neurological diseases.

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T cells are key to maintaining cancer remissions from chemotherapy

Posted by Erin Podolak | Jul 12, 2022

Stimulating the adaptive immune response can improve outcomes for ALL treated with chemotherapy.

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Research points to a way to reduce cachexia, a cancer-induced muscle wasting disorder

Posted by Erin Podolak | May 24, 2022

Muscle signaling provide clues for treatment of the muscle-wasting disorder cachexia, which affects cancer patients.

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Five years later: gene therapy for ‘bubble boy’ disease

Posted by Alex Generous, PhD | May 19, 2022

Interim results point to enduring immune function following gene therapy for Infants with ‘bubble boy’ disease

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Metabolic processes may yield a new therapeutic window for hard-to-treat brain tumors

Posted by Erin Podolak | Apr 22, 2022

In his laboratory at St. Jude, Stephen Mack, PhD, is researching how metabolic and epigenetic pathways might be perturbed to help treat DIPG, a lethal childhood brain tumor.

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The double-edged sword of being both parent and blood stem cell donor

Posted by Alex Generous, PhD | Mar 8, 2022

What are the potential psychological and emotional risks and rewards for parents who serve as their children’s bone marrow donors?

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