Category: Research

Xu Yang and Yizhen Li in a laboratory

T cells are key to maintaining cancer remissions from chemotherapy

Posted by Erin Podolak | Jul 12, 2022

Stimulating the adaptive immune response can improve outcomes for ALL treated with chemotherapy.

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Fabio Demontis

Research points to a way to reduce cachexia, a cancer-induced muscle wasting disorder

Posted by Erin Podolak | May 24, 2022

Muscle signaling provide clues for treatment of the muscle-wasting disorder cachexia, which affects cancer patients.

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Ewelina Mamcarz with colleagues and patient

Five years later: gene therapy for ‘bubble boy’ disease

Posted by Alex Generous, PhD | May 19, 2022

Interim results point to enduring immune function following gene therapy for Infants with ‘bubble boy’ disease

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Stephen Mack, MD, PhD

Metabolic processes may yield a new therapeutic window for hard-to-treat brain tumors

Posted by Erin Podolak | Apr 22, 2022

In his laboratory at St. Jude, Stephen Mack, PhD, is researching how metabolic and epigenetic pathways might be perturbed to help treat DIPG, a lethal childhood brain tumor.

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Photo of Parent holding sick child's hand

The double-edged sword of being both parent and blood stem cell donor

Posted by Alex Generous, PhD | Mar 8, 2022

What are the potential psychological and emotional risks and rewards for parents who serve as their children’s bone marrow donors?

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CoNGA: Deciphering the dance of T-cell differentiation

Posted by Stefan Schattgen, PhD | Aug 23, 2021

St. Jude scientists have created an algorithm to help group T-cells by their function by evaluating two different types of data, T-cell receptor sequences and gene expression.

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Haitao Pan, PhD

St. Jude biostatisticians create a novel clinical trial design software

Posted by Katy Hobgood | Jul 27, 2021

Description: St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.

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Leaf with water droplets

For the growing number of childhood cancer survivors, five-year survival is just the beginning

Posted by AnnaLynn Williams, PhD | May 11, 2021

As cancer survivorship changes, new benchmarks must be set to redefine survivorship research and treatment success.

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A 3D print of influenza virus shows the yellow surface covered with proteins called hemagglutinin (colored blue) and neuraminidase (colored red) that enable the virus to enter and infect human cells. Image provided by the National Institutes of Health.

Immune markers offer clues to antibody production in response to flu

Posted by Mary Powers | Apr 7, 2021

Scientists are learning more about antibody production in response to flu, including how they develop from helper T cells and monocytes.

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Different types of pediatric cancer treatments are ototoxic, or damaging to the ears. As cancer treatments become more effective and survival rates increase, we’re getting a better picture of how various treatments affect patients later on.

What we’ve found out about hearing loss and cognitive function in children

Posted by Johnnie Bass, AuD, PhD | Mar 25, 2021

This study, to our knowledge, is the first to objectively measure hearing and neurocognitive function in a large cohort of long-term survivors of childhood cancer stratified by treatment exposures.

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